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The government places a cap on how much drug manufacturers can charge, which keeps medications affordable for everyone. The government places a cap on how much drug manufacturers can charge, which keeps medications affordable for everyone. Crestor Mechanism of ActionIt catalyzes HMG-CoA conversion to mevalonate, which is a step in cholesterol biosynthesis. Crestor Mechanism of ActionIt catalyzes HMG-CoA conversion to mevalonate, which is a step in cholesterol biosynthesis. In fact theStatins are known as HMG-CoA reductase inhibitors because they work by blocking production of the liver enzyme responsible for creating a type of cholesterol in the body (another source of cholesterol is diet). In fact theStatins are known as HMG-CoA reductase inhibitors because they work by blocking production of the liver enzyme responsible for creating a type of cholesterol in the body (another source of cholesterol is diet). 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